منابع مشابه
Paneth cells
turned out, these beetles were not only active for most of the day (and night), but also showed an extremely robust and easily manipulated orientation behaviour. As soon as these strong insects are in the possession of a dung ball, they will unconditionally and immediately transport this package of food along a given course until they reach soft and easily manipulated ground. Here, they dig dow...
متن کاملPaneth cells and necrotizing enterocolitis
Necrotizing enterocolitis (NEC) is a common and devastating disease of premature infants. Immaturity of the innate immune system of the gut is central to the pathogenesis of NEC. Recent studies suggest a key role for Paneth cells in this disease. Addressing basic questions on the development and function of immature Paneth cells may shed light on the puzzling pathophysiology of NEC. Current ani...
متن کاملPaneth cells in intestinal physiology and pathophysiology
Small intestinal mucosa is characterised by villus forming connective tissues with highly specialised surface lining epithelial cells essentially contributing to the establishment of the intestinal border. In order to perform these diverse functions, spatially distinct compartments of epithelial differentiation are found along the crypt-villus axis, including Paneth cells as a highly specialise...
متن کاملStem Cell Niches: Famished Paneth Cells, Gluttonous Stem Cells
Adult tissue stem cells adjust to environmental changes. A new study in the mouse intestine reveals that caloric restriction causes Paneth cells to repress mTORC1 signaling; this in turn stimulates proliferation of neighboring stem cells.
متن کاملN0d2 Gene Expression in Paneth Cells and Monocytes
Introduction: Mutations in the NOD2 gene are associated with the development of Crohn’s disease, an inflammatory disorder of the gastrointestinal tract. The NOD2 protein induces cellular activation in response to the bacterial antigen muramyl dipeptide (MDP). The NOD2 gene is mainly expressed by circulating blood monocytes although NOD2-associated Crohn’s disease involves mainly the terminal il...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2011
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2011.08.030